Center for Medical Mycology

"From the Test-Tube to the Patient"

University Hospitals of Cleveland and Case Western Reserve University

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  Fungal Biology, Biochemistry and Moleclar Biology Fungal Biofilms

Center for Medical Mycology (CMM) is a unique institutional resource for the study of fungal diseases from the test tube to the patient, which serves as a mycology reference center providing services to clinicians and the pharmaceutical industry. We also perform molecular level research on areas including fungal pathogenesis, virulence and formation of fungal biofilm, as well as clinically relevant studies in fungal biology. The faculty and staff at the Center possess high ethical standards and are committed to being effective, responsible and accountable.

Click here to download a brochure (PDF, 1.6 MB) describing the services offered by our Center.

Our Mission

To provide reliable patient oriented services which will support University Hospitals' long standing commitment to provide quality patient management and innovative research and to strengthen Case Western Reserve University as a major biomedical research university by making important scholarly contributions to the fund of mycological center of excellence, recognized as having innovative research, educational and clinical programs.

 

 

OverviewDifferent fungi

Research at the CMM is devoted to the following main areas:

  1. A basic science area focusing on the biology of fungal biofilms, determination of virulence factors responsible for the pathogenesis of fungi including dermatophytes, Candida albicans and Cryptococcus neoformans, and
  2. A pre-clinical laboratory area concentrating on development of reference method for antifungal susceptibility testing.
  3. An in vivo animal center
  4. Studies of mechanism of action of different antifungal agents.

In an effort to delineate the pathogenicity factors of fungi causing skin infections, we utilize the methods and approaches we developed in our previous investigations addressing the virulence of fungi causing systemic infections to research on dermatophytes. Additionally,  we have developed standard methods for antifungal susceptibility testing of dermatophytes. To date, both of these areas have received little or no attention even though infections with these agents are increasing and may cause devastating systemic infections in the immunocompromised host, especially in those whose neutrophil and macrophage functions is deficient.

Of particular relevance in the clinical laboratory area is the microdilution method we developed for determining the susceptibility of Cryptococcus neoformans. We have shown that this method is reproducible, easy to perform and has both intra- and inter-laboratory agreement. Critically, we demonstrated that cryptococcal susceptibility to fluconazole is an important predictor of treatment success for patients with acute AIDS-associated cryptococcal meningitis. This method was adopted as part of the NCCLS Reference Method for Antifungal Susceptibility Testing. Developing a susceptibility method for dermatophytes is currently being performed at CMM.

Strong support for these research efforts are drawn from different sources including the established faculty of the Department of Dermatology, associated researchers, and newly appointed faculty of the Center for Medical Mycology at Case Western Reserve University. Existing faculty provides a wealth of expertise in the clinical studies, pharmacology, immunology and molecular biology of the skin and skin diseases, and medical mycology. The presence of faculty with a wide array of multi-disciplinary expertise allows for addressing a research issue from different angles.

 

Contact Information

Telephone (216) 844-8580, Toll-free: 1-888-4MYC-LAB
FAX (216) 844-1076
Postal Address 11100 Euclid Avenue, LKS-5028, Cleveland, OH 44106-5028
Electronic Mail Prof. Mahmoud A. Ghannoum, Director, Center for Medical Mycology
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